The use of a cleanroom in the production of commercial bioprinted products is essential, as clean manufacturing conditions are among the key regulatory requirements in this field. Bioprinting technology typically operates in sensitive environments that are highly vulnerable to microbial contamination, airborne particles, and temperature fluctuations. Even trace amounts of contamination can lead to cell death, impaired function of printed tissues, or undesirable immune responses in the body. By precisely controlling environmental factors such as particulate levels, temperature, humidity, and air pressure, a cleanroom enables the safe, reproducible, and standardized production of biological products. It plays a crucial role in ensuring the quality and safety of bioprinting applications for both clinical and research purposes.